Publications
2023
Medenbach J & Tschochner H: Nobel Prize for physiology or medicine in 2023: how to dupe the cellular innate immune system using modified RNA for therapeutic treatment. Pflugers Archiv – European Journal of Physiology, 2023, doi: 10.1007/s00424-023-02895-9
Bleckmann A, Spitzlberger N, Denninger P, Ehrnsberger HF, Wang L, Bruckmann A, Reich S, Holzinger P, Medenbach J, Grasser KD, Dresselhaus T: Cytosolic RGG RNA-binding proteins are temperature sensitive flowering time regulators in Arabidopsis. Biol Chem., 2023, doi: 10.1515/hsz-2023-0171
Klein T, Funke, F, Rossbach O, Lehmann G, Vockenhuber M, Medenbach J, Suess B, Meister G, Babinger P: Investigating the Prevalence of RNA-Binding Metabolic Enzymes in E. coli. Int. J. Mol. Sci, 2023, doi: 10.3390/ijms241411536
Pichler M, Meindl A, Romberger M, Eckes-Shephard A, Nyberg-Brodda C-F, Buhigas C, Llaneza-Lago S, Lehmann G, Hopes A, Meister G, Medenbach J, Mock T: Ribosome Profiling in the Model Diatom Thalassiosira pseudonana. Current Protocols 2023, doi: 10.1002/cpz1.843
Meindl A, Romberger M, Lehmann G, Eichner N, Kleemann L, Wu J, Danner J, Boesl M, Mesitov M, Meister G, König J, Leidel SA, Medenbach J: High resolution and rapid ribosome profiling from low-input samples. Nucleic Acids Res., 2023, doi: 10.1093/nar/gkad459
2022
Meindl A, Romberger M, Lehmann G, Eichner N, Kleemann L, Wu J, Danner J, Boesl M, Mesitov M, Meister G, König J, Leidel S, Medenbach J: High resolution and rapid ribosome profiling from low-input samples. bioRxiv, 2022, doi: 10.1101/2022.09.23.509038
Magnus CL, Hiergeist A, Schuster P, Rohrhofer A, Medenbach J, Gessner A, Peterhoff D, Schmidt B: Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab. Frontiers in Immunology, 2022 Aug 24;13:966236. doi: 10.3389/fimmu.2022.966236
2021
Salerno-Kochan A, Horn A, Ghosh P, Nithin C, Kościelniak A, Strauss D, Rossbach O, Bujnicki JM, Gaik M, Medenbach J, Glatt S: Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26. bioRxiv, 2021, https://doi.org/10.1101/2021.09.20.461029; Life Science Alliance. 2022 May 5;5(8):e202201418. doi: 10.26508/lsa.202201418.
2020
Kopczynski D, Hentschel A, Coman C, Schebb NH, Hornemann T, Mashek DG, Hartung NM, Shevchuk O, Schött H-F, Lorenz K, Torta F, Burla B, Zahedi RP, Sickmann A, Kreutz MR, Ejsing CS, Medenbach J, and Ahrends J: Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics. Analytical Chemistry, 2020, 92(20):p13672–13676. https://doi.org/10.1021/acs.analchem.0c02793
Reich S, Nguyen CDL, Has C, Steltgens S, Soni H, Coman C, Freyberg M, Bichler A, Seifert N, Conrad D, Knobbe-Thomsen CB, Tews B, Toedt G, Ahrends R, and Medenbach J: A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites. Nature Communications, 2020, 11, Article number: 2936, DOI:10.1038/s41467-020-16747-y
Herdt O, Reich S, Medenbach J, Timmermann B, Olofsson D, Preußner M and Heyd F: The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation. RNA Biology, 2020, 17(6):p843-856,. https://doi.org/10.1080/15476286.2020.1732701
2019
Nguyen C, Malchow S, Reich S, Loroch S, Sickmann A, Tews B, Medenbach J, and Ahrends R: PRM-deep: A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells. Scientific Reports, 2019, 9, Article number: 8836, https://doi.org/10.1038/s41598-019-45237-5
Müller-McNicoll M, Rossbach O, Hui J, and Medenbach J: Auto-regulatory feedback by RNA-binding proteins. Journal of Molecular Cell Biology 2019, 11(10): p930–939, https://doi.org/10.1093/jmcb/mjz043
Wirthschaft P, Bode J, Soni H, Dietrich F, Krüwel T, Fischer B, Knobbe-Thomsen CB, Rossetti G, Hentschel A, Mack N, Schönig K, Breckwoldt MO, Schmandke A, Pusch S, Bendszus M, Schwab ME, Medenbach J, von Deimling A, Kool M, Herold-Mende C, Reifenberger G, Ahrends R, and Tews B: RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading gliomas. Acta Neuropathologica, 2019, 138:p275–293, https://doi.org/10.1007/s00401-019-02021-z
Urdaneta EC, Vieira C , Hick T, Wessels HH, Moschall R, Medenbach J, Ohler U, Granneman S, Selbach M, and Beckmann BM: Purification of Cross-linked RNA-Protein Complexes by Phenol-Toluol Extraction. Nature Communications, 2019, 1;10(1):990, https://doi.org/10.1038/s41467-019-08942-3
Moschall R, Rass M, Rossbach O, Lehmann G, Kullmann L, Eichner N, Strauss D, Meister G, Schneuwly S, Krahn M, and Medenbach J: Sister of Sex-lethal antagonizes Sxl-dependent alternative splicing to maintain a male-specific gene expression pattern in Drosophila. Nucleic Acids Res. Nucleic Acids Res., 2019, 18;47(5):2276-2288, https://doi.org/10.1093/nar/gky1284
2018
Moschall R, Strauss D, Garcia-Beyaert M, Gebauer F, Medenbach J: Drosophila Sister-of-Sex-lethal is a repressor of translation. RNA, 2018, 24:149-58, https://rnajournal.cshlp.org/content/24/2/149.full
Knüppel R, Christensen RH, Gray FC, Esser D, Strauß D, Medenbach J, Siebers B, MacNeill SA, LaRonde N, Ferreira-Cerca S: Insights into the evolutionary conserved regulation of Rio ATPase activity. Nucleic Acids Res. 2018, 16;46(3):1441-1456, https://doi.org/10.1093/nar/gkx1236
2017
Moschall R, Gaik M, Medenbach J.: Promiscuity in post-transcriptional control of gene expression: Drosophila Sex-lethal and its regulatory partnerships. FEBS Lett. 2017, 591(11):1471-1488, https://doi.org/10.1002/1873-3468.12652
2016
Schneider T., Hung L-S., Schreiner S., Starke S., Eckhof H., Rossbach O., Reich S., Medenbach J., and Bindereif A.: CircRNA-protein complexes: IMP3 protein component defined subfamily of circRNPs. Scientific Reports, 2016, 6(31313), https://doi.org/10.1038/srep31313
Beckmann BM., Castello A., and Medenbach J.: The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions. Pflugers Arch., 2016,468(6):1029-40, https://doi.org/10.1007/s00424-016-1819-4
before 2106
Rösel TD, Medenbach J, Damianov A, Schreiner S, and Bindereif A. Sedimentation Analysis of Ribonucleoprotein Complexes. Handbook of RNA Biochemistry: Second, Completely Revised and Enlarged Edition. R. K. Hartmann, A. Bindereif, A. Schön and E. Westhof. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. 2014. IV:1055-66. ISBN: 978-3-527-32776-8
Medenbach J., Seiler M., and Hentze MW.: Translational control via protein-regulated upstream open reading frames. Cell, 2011, 145(6):902-13, https://doi.org/10.1016/j.cell.2011.05.005
– Featured in: Yao P. and Fox PL: Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes. Genome Biology, 2011, 12:121.
Rösel TD.*, Hung LH.*, Medenbach J.*, Donde K., Starke S., Benes V., Rätsch G., and Bindereif A.: RNA-Seq analysis in mutant zebrafish reveals role of U1c protein in alternative splicing regulation. EMBO Journal, 2011, 30(10):1965-76. (* these authors contributed equally), https://dx.doi.org/10.1038%2Femboj.2011.106
Pérard J., Rasia R., Medenbach J., Ayala I., Boisbouvie, J., Drouet E., and Baudin F.: Human initiation factor eIF3 subunit interacts with HCV IRES RNA through its N-terminal RNA recognition motif. FEBS Lett., 2009, 583(1): 70-4. https://doi.org/10.1016/j.febslet.2008.11.025
Licht K.*, Medenbach J.*, Lührmann R., Kambach C., and Bindereif A.: 3‘-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins. RNA, 2008, 4(8): 1532-8. (* these authors contributed equally) https://doi.org/10.1261/rna.1129608
Trede N.S.*, Damianov A.*, Medenbach J.*, Hung L.-H., Weber G.J., Paw B.H., Zhou Y., Hersey C., Zapata A., Keefe M., Barut B.A., Stuart A.B., Katz T., Amemiya C.T., Zon L.I., and Bindereif A.: Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc. Natl. Acad. Sci. USA, 2007, 104(16): 6608-13. (* these authors contributed equally), https://doi.org/10.1073/pnas.0701919104
Medenbach J., Schreiner S., Liu S., Lührmann R., and Binderei, A.: Human U4/U6 snRNP Recycling Factor p110: Mutational Analysis Reveals the Function of the Tetratricopeptide Repeat Domain in Recycling, Molecular and Cellular Biology, 2005, 24(17): 7392-7401. https://doi.org/10.1128/MCB.24.17.7392-7401.2004
Medenbach, J., Damianov, A., Schreiner, S., and Bindereif, A.: Sedimentation Analysis of Ribonucleoprotein Complexes. Handbook of RNA Biochemistry. R. K. Hartmann, A. Bindereif, A. Schön and E. Westhof. Weinheim, Wiley-VCH., 2005, 1: 428-437. Print ISBN:9783527308262 – Online ISBN:9783527619504 – DOI:10.1002/9783527619504