The ability to sequence entire genomes and transcriptomes in ever shorter timeframes has far outpaced our understanding of how gene expression is controlled. Even though we have a firm knowledge of the general principles of gene expression, we are still far from a holistic and comprehensive understanding of the underlying regulation. It is one of the major challenges in modern biology to gain detailed understanding of the regulatory principles and networks that control gene expression.

To better understand gene expression control, we are focusing on two major subjects: